Chiba University Sep 17 2025 Modern lifestyles and dietary changes have significantly increased the consumption of high-fat foods, contributing to a steep rise in the prevalence of obesity, diabetes, and metabolic disorders. Furthermore, a high-fat diet (HFD) is linked to cognitive impairments and neurodegeneration and has been shown to worsen the pathology of Alzheimer's disease-a progressive neurodegenerative condition-in mouse models. Yet, the underlying mechanisms remain largely elusive.