Frontiers Journals Dec 26 2024 Adenosine deaminase 2 (ADA2) has been identified as a regulator of toll-like receptor 9 (TLR9) activation in response to nucleic acids, according to a recent study. ADA2, previously known for its role in catalyzing the deamination of adenosine to inosine, is revealed to function as an intracellular DNA-binding protein that controls TLR9 activation in plasmacytoid dendritic cells (pDCs). This discovery provides insights into the functional differences among three

Tag-uri: DNA