Frontiers Mar 25 2025 The most comprehensive model of the brain’s metabolism, incorporating more than 16,800 biochemical interactions, has identified key targets to reverse the age-related decline in brain function. The new analysis of complex interactions between neuronal activity, metabolism, and blood flow found that restoring blood chemistry to youthful levels through diet, exercise, and supplements could improve the brain’s resilience to damage. Scientists can now use this model to find