Vanderbilt University Medical Center May 29 2026 In a new study published in JAMA , the diagnostic yield of transbronchial lung biopsy was significantly higher when using a cryoprobe versus forceps in a group of patients with pulmonary nodules or masses, recent lung transplant, and diffuse parenchymal lung disease. A transbronchial lung biopsy is a minimally invasive procedure in which a bronchoscope - a thin, lighted tube - is guided through the nose or mouth into the lungs. Tools are then