The New Orleans Saints begin the 2025 NFL season Sunday when they host the Arizona Cardinals inside the Superdome. BetMGM lists New Orleans as a 6.5 point underdog, a line that signals low external expectations for the opener. Arizona enters with a balanced roster led by quarterback Kyler Murray and rising receiver Marvin Harrison Jr. The Saints counter with change at the top, as Kellen Moore makes his debut as head coach. Betting analyst Quinn Allen said “the Cardinals defense is built to make