Metformin appears to diminish exercise-driven improvements in vascular health, fitness, and blood sugar control. Credit: Shutterstock A widely used medication for diabetes prevention may unexpectedly interfere with one of the most reliable ways to lower disease risk: regular physical activity. A Rutgers-led team reported in The Journal of Clinical Endocrinology & Metabolism that metformin appeared to weaken several important benefits normally gained from exercise. These include improvements in