By Priyanjana Pramanik, MSc. Reviewed by Susha Cheriyedath, M.Sc. Nov 18 2025 A rare intracranial recording shows how a low-frequency brain signal vanished during tirzepatide-associated symptom relief and resurfaced weeks before dysregulated eating returned. Study: Brain activity associated with breakthrough food preoccupation in an individual on tirzepatide . Image Credit: Chandan Tripathy / Shutterstock In a recent study in  Nature Medicine , researchers examined how tirzepatide, a therapy