DNA methylation "fingerprints" identify primary sites in metastatic cancers
Andreea Neblea
American Association for Cancer Research Apr 21 2026 A machine learning model analyzing CpG-based DNA methylation accurately predicted the origin of many different cancer types in patients with cancers of unknown primary (CUP), according to research presented at the American Association for Cancer Research (AACR) Annual Meeting 2026, held April 17-22. CUP are metastatic malignancies in which the primary cancer site could not be identified. These cancers are often associated with poorer outcomes,
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