By Pooja Toshniwal Paharia Reviewed by Susha Cheriyedath, M.Sc. Mar 30 2026 A sweeping new review shows how disruptions in the gut microbiome may fuel obesity, insulin resistance, and cardiovascular risk, while pointing to diet and other microbiome-focused strategies that could help restore metabolic balance. Integrative mechanistic framework linking gut dysbiosis to systemic metabolic dysfunction. Arrows indicate the progression of events from exogenous and host-related factors to gut