FGFR2 identified as key driver in KRAS-mutated pancreatic cancer progression
Andreea Neblea
American Association for Cancer Research Apr 2 2025 Bottom line: Precancerous pancreatic lesions and some pancreatic ductal adenocarcinoma (PDAC) tumors harboring KRAS mutations had higher-than-normal expression of the FGFR2 protein, and FGFR2 inactivation delayed KRAS-mutated PDAC development in mice. Journal in which the study was published: Cancer Research, a journal of the American Association for Cancer Research Author: Claudia Tonelli, PhD, a research investigator in the laboratory of
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