Frontiers Journals May 8 2025 A recent study published in Engineering has shed new light on the mechanisms underlying the metastasis of head and neck squamous cell carcinoma (HNSCC). The research identified enolase 2 (ENO2), a crucial glycolytic enzyme, as a significant factor associated with lymphatic metastasis in HNSCC. HNSCC is an aggressive cancer with a relatively low 5-year overall survival rate. Cervical lymph node metastasis is a major cause of cancer-related death in HNSCC patients,