Chinese Academy of Sciences Jun 3 2026 Ferroptosis has become a promising area in cancer research because it may provide a way to target tumor cells that evade other better-known forms of programmed cell death, such as apoptosis and necroptosis. Glutathione peroxidase 4 (GPX4) is a central defense against ferroptosis, neutralizing the lipid peroxides that can damage cell membranes. GPX4 exists in cytosolic, mitochondrial, and nuclear forms, but the regulation of nGPX4 remains much less