Children's Hospital Los Angeles Mar 14 2025 A new research study led by Jonathan D. Santoro, MD, Director of the Neuroimmunology Program at Children's Hospital Los Angeles, shows evidence of dysfunction of the blood-brain barrier and inflammation in the central nervous system in individuals with Down syndrome Regression Disorder (DSRD). The new study, "Evidence of blood–brain barrier dysfunction and CSF immunoglobulin synthesis in Down Syndrome Regression Disorder," was published in the Annals