University of Pennsylvania Jan 9 2025 Opioid misuse and specifically opioid use disorder (OUD), continues to represent a significant U.S. public health threat, with more than 6 million Americans aged 12 and older meeting the criteria for OUD in 2022. Efforts to ease the crisis have included the development of genetic testing to identify individuals most at risk for OUD. New research, out today in JAMA Network Open, questions the usefulness of 15 genetic variants from an algorithm meant to