University of Connecticut Mar 14 2025 In  Nature Neuroscience , UConn School of Medicine researchers have revealed a new scientific clue that could unlock the key cellular pathway leading to devastating neurodegenerative diseases like Alzheimer's disease, and the progressive damage to the brain's frontal and temporal lobes in frontotemporal degeneration (FTD) and the associated disease amyotrophic lateral sclerosis (ALS). The study, "Endothelial TDP-43 Depletion Disrupts Core Blood-Brain