Frontiers Journals Apr 2 2025 Inherited retinal degeneration (IRD) encompasses various disorders characterized by progressive loss of retinal photoreceptor cells, ultimately leading to vision loss and blindness. Among the numerous genetic factors implicated in IRD, mutations in the CRB1 gene stand out as significant contributors to severe forms of retinal degeneration, including retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA). Recent research has unveiled a novel mechanism