Are the 49ers in trouble after key injuries to Brock Purdy & George Kittle? | First Things First Nick Wright breaks down the San Francisco 49ers’ injury concerns following Week 1. With Brock Purdy uncertain for Week 2 against the New Orleans Saints and George Kittle expected to miss a few weeks, Nick explains why these injuries could put San ... NEW You can now listen to Fox News articles! Christian McCaffrey and the San Francisco 49ers’ defense had a night. The star running back had 201 yards