Xia & He Publishing Inc. Feb 13 2026 Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy, affecting a significant proportion of patients who develop drug-resistant epilepsy. Surgical interventions, particularly stereoelectroencephalography (SEEG)-guided temporal lobe resection (TLR) and SEEG-guided responsive neurostimulation (RNS), have emerged as pivotal treatment options. This systematic review aims to compare the efficacy, safety, and quality of life (QoL) outcomes