By Dr. Sanchari Sinha Dutta, Ph.D. Reviewed by Lauren Hardaker Jan 20 2026 A large Danish trial analysis suggests high-dose flu vaccines may offer extra protection against serious influenza-related hospitalizations in seniors. Study: High-Dose vs Standard-Dose Influenza Vaccine in Older Adults With Diabetes . Image credit: Andrew Angelov/Shutterstock.com A study published in  JAMA Internal Medicine suggests that high-dose influenza vaccine is associated with lower rates of selected influenza-