By Priyanjana Pramanik, MSc. Reviewed by Susha Cheriyedath, M.Sc. Jan 21 2026 A small but rigorous randomized trial suggests paracetamol may be a feasible alternative to ibuprofen for late PDA treatment, while underscoring the need for larger multicenter studies to guide neonatal care. Study: Paracetamol or ibuprofen? A pilot study comparing rescue therapy for PDA in preterm infants within the first month . Image Credit: Jana Kollarova / Shutterstock In a recent article published in the journal