Chinese Academy of Sciences Mar 3 2025 Stress granules (SGs) are transient organelles that form when cells experience stress, serving as critical hubs for RNA metabolism and cellular survival. Comprised of RNA-binding proteins and nucleic acids, SGs exhibit liquid-like properties and are involved in processes like mRNA regulation and protein synthesis. However, the dysfunction of SGs has been implicated in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and