A team co-led by UCL researchers has reversed Alzheimer's disease pathology in mice using nanoparticles that help the brain to clear away toxic amyloid proteins naturally. Unlike traditional nanomedicine, which relies on nanoparticles as carriers for therapeutic molecules, the approach utilised nanoparticles that are bioactive in their own right, known as "supramolecular drugs". The work has been published in the journal Signal Transduction and Targeted Therapy . Instead of targeting neurons