University of Birmingham Apr 13 2026 Scientists investigating the naturally occurring immunopeptide PEPITEM have shown reductions in arthritic joint swelling to a degree comparable to the current standard of care, and reduce the inflammatory changes that cause joint damage. PEPITEM (Peptide Inhibitor of Trans-Endothelial Migration) was first discovered by researchers at the University of Birmingham, who characterised the Adiponectin-PEPITEM pathway.  This tightly orchestrated process regulates