'Partial reprogramming' of engram neurons restores memory performance in mice

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Ecole Polytechnique Fédérale de Lausanne Feb 10 2026 Age-related memory decline and neurodegenerative diseases like Alzheimer's are often thought of as irreversible. But the brain is not static; neurons continually adjust the strength of their connections, a property called "synaptic plasticity", and this flexibility is the basis of memory and learning. But aging and Alzheimer's disrupt many cell processes that support synaptic plasticity. A key question is whether and how the affected cells

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