Boston University School of Medicine Feb 10 2026 Hypermobile Ehlers–Danlos syndrome (hEDS) is one of the most common heritable connective tissue disorders. Early estimates have reported that this genetic disorder affects at least one in 5,000 individuals and more recently it has been estimated to affect upwards of 1-3% of the population worldwide. Clinically, hEDS is characterized by generalized joint hypermobility, tissue fragility including capillary fragility associated with easy bruising,