By Dr. Sanchari Sinha Dutta, Ph.D. Reviewed by Lauren Hardaker Jul 4 2025 Can probiotics reverse early ovarian decline? A new study in mice suggests they might restore hormonal balance and microbial health after chemotherapy-induced damage. Study:  Probiotics may improve vaginal microbiota, metabolic disorders and ovarian function-related markers by modulating gut microbiota in POI mice . Image credit: ALIOUI MA/Shutterstock.com A study conducted by Nanjing Medical University researchers