By Pooja Toshniwal Paharia Reviewed by Susha Cheriyedath, M.Sc. Apr 14 2026 A large first-trimester study found little evidence that SARS-CoV-2 commonly infects placental tissue, but it also showed that even limited viral presence can reshape immune signaling at the site where pregnancy begins. Study: SARS-CoV-2 infection during the first trimester leads to profound immune dysregulation at the maternal-fetal interface despite limited virus detection in placental tissues . Image Credit: Kateryna