By Tarun Sai Lomte Reviewed by Susha Cheriyedath, M.Sc. Apr 14 2026 A new benchmark shows that even the most advanced AI models can often reach the final diagnosis but still falter when clinicians must weigh uncertainty, build a differential diagnosis, and decide what to test next. Study: Large Language Model Performance and Clinical Reasoning Tasks . Image Credit: Iryna Pohrebna / Shutterstock In a recent study published in  JAMA Network Open , researchers investigated the clinical reasoning