Science and Technology Review Publishing House Oct 10 2025 Background Abdominal aortic aneurysm (AAA) is a life-threatening vascular disorder that primarily affects elderly males. It often develops asymptomatically, yet aneurysm rupture can lead to rapid fatality. Currently, no effective pharmacological therapies are available to halt or reverse AAA progression. Previous studies have highlighted the phenotypic switching of vascular smooth muscle cells (VSMCs) as a central event in AAA