For Dr. Joseph Cacchione, the math on GLP-1 drugs stopped making sense. The CEO of the Philadelphia-based nonprofit hospital system Jefferson said his organization now spends more on prescription drug coverage — fueled by the soaring use of weight loss medications like Wegovy and Zepbound — than it does on inpatient care. Jefferson has dozens of hospitals across the region. It also has its own insurance plan for its 65,000 employees. A decade ago, prescription drugs made up about 14% of