By Priyanjana Pramanik, MSc. Reviewed by Danielle Ellis, B.Sc. Oct 30 2024 Findings indicate that the vitamin is effective and safe for managing NLCs in people over 65. Study: Vitamin K2 in Managing Nocturnal Leg Cramps A Randomized Clinical Trial . Image Credit: staras/Shutterstock.com In a recent study published in JAMA Internal Medicine , researchers examined the effects of vitamin K 2 on the severity, duration, and frequency of nocturnal leg cramps (NLCs) among older people. Background