Ehime University Apr 3 2025 Atopic dermatitis is an allergy affecting approximately 10% of the Japanese population, with symptoms closely related to social stress. In socially active adults, the disease often becomes chronic. In affected areas, infiltrating immune cells secrete inflammatory cytokines, which contribute to symptom development. While these cytokines normally play a protective role against pathogenic microbes under physiological conditions, their excessive and prolonged release in