Intercellular heme transfer pathway sustains red blood cell production under stress

George Mihalcea

University of Maryland School of Medicine Apr 25 2026 Scientists have long been puzzled by how maturing red blood cells manage to produce all the hemoglobin they need to carry oxygen to tissues, even after shedding the vital structures they need to produce it. Now, new University of Maryland School of Medicine (UMSOM) research has found a missing piece to the puzzle: In the final stages of their maturation, red blood cells can import heme, a crucial, iron-containing component of hemoglobin,

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