ROME — Pope Leo XIV on Tuesday made his first major appointment of a woman to the Holy See hierarchy, promoting Italian Sister Alessandra Smerilli to head the Vatican office responsible for migrants , the environment and development. Smerilli, an economist, is currently the No. 2 in the Dicastery for Promoting Integral Human Development. As prefect, she replaces the retiring Canadian Cardinal Michael Czerny, who turns 80 this month. With the appointment of Smerilli, Leo appears to be following