Molecular keyhole discovery offers new hope for personalized pain therapies The lock and key model in the TRPM3 channel TRPM3 and trigeminal neuralgia: a key to severe pain Master key for targeted therapies
Lucian Nemoiu
Vlaams Instituut voor Biotechnologie Apr 21 2026 Researchers at VIB, VUB, and KU Leuven have identified a tiny binding site, a molecular 'keyhole', in the TRPM3 ion channel, a crucial sensor in pain signaling. TRPM3 is also linked to rare neurodevelopmental disorders and epilepsy. In a recent study published in Nature Communications , the researchers found that even the slightest change in this keyhole can radically switch the channel's behavior, explaining how certain mutations can flip the
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