Polyglycine aggregates disrupt tRNA splicing and drive neurodegeneration
Lucian Nemoiu
Mass General Brigham Jul 17 2025 Raghu R. Chivukula, MD, PhD, a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is the senior author of a paper published in Science, "Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders." Q: How would you summarize your study for a lay audience? Neurodegenerative disorders, such as Alzheimer's disease and
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