By Dr. Liji Thomas, MD Reviewed by Lauren Hardaker Jun 25 2026 A 13-year UK Biobank analysis suggests that neuroticism, adversity, and other psychosocial pressures may explain more of the population burden of depression and anxiety than physiological risk factors alone. Study: Associations of modifiable risk factors with depression and anxiety in women and men: evidence from the UK Biobank . Image Credit: manka_web / Shutterstock Given the high global burden of depression and anxiety, it is