Mapping cerebellar nuclei outputs in an autism mouse model
Educatie
Higher Education Press Dec 27 2024 The cerebellum plays a critical role in both motor and non-motor functions, and its dysfunction is linked to various mental disorders, including autism. This study maps the three-dimensional distributions of 50,168 target neurons of cerebellar nuclei (CN) in wild-type and Nlgn3 R451C mutant mice. The researchers found that the Nlgn3 R451C mutation differentially affects projections from CN to the thalamus, midbrain, and brainstem. Specifically, the mutation
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