Animal research reveals metabolic differences between tirzepatide and semaglutide

Magda Gheorghiță

European Association for the Study of Obesity May 14 2025 New animal research being presented at this year's European Congress on Obesity (ECO) in Malaga, Spain (11-14 May), reveals distinct metabolic adjustments to tirzepatide and semaglutide treatment, with tirzepatide temporarily increasing energy expenditure and semaglutide initially reducing energy expenditure. Importantly, the biggest metabolic changes happen directly after treatment and disappear quickly after treatment is stopped. Anti-

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