A review of studies on fecal transplants alleviating symptoms of depression has found the treatment works best when the packages of helpful microbes are delivered straight to our gut through our butts, as opposed to an oral route. This was particularly the case for people who also have irritable bowel syndrome , the meta-analysis determined. However, they also found that the effects diminished by 6 months. "Fecal microbiota transplantation exerts a sustained and progressively enhanced