European Society of Cardiology (ESC) Sep 3 2025 Compared with crushed ticagrelor, intravenous cangrelor provided immediate, effective platelet inhibition, with no increase in major bleeding and lower mortality rates in patients with acute myocardial infarction and cardiogenic shock, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025. Cardiogenic shock is a life-threatening condition in which the heart cannot pump enough blood to meet the body's needs.