By Priyanjana Pramanik, MSc. Reviewed by Susha Cheriyedath, M.Sc. Sep 14 2025 By reframing migraine as an energy deficit disorder, this review spotlights ketogenic therapy as a targeted metabolic intervention that could lower attack frequency and drug reliance, pending high-quality trials and structured monitoring. Review: The Hypometabolic State of the Migraine Brain: Is a Ketogenic Diet the Answer? Image Credit: Lightspring / Shutterstock In a recent  Brain and Behavior review paper,