By Tarun Sai Lomte Reviewed by Susha Cheriyedath, M.Sc. Apr 13 2026 A new mouse study suggests that sweeteners consumed by parents may reshape gut bacteria, microbial metabolites, and metabolic signals in offspring, with sucralose leaving the strongest multigenerational imprint. Study: Artificial and natural non-nutritive sweeteners drive divergent gut and genetic responses across generations . Image Credit: Andrii Zastrozhnov / Shutterstock In a recent study published in the journal  Frontiers