Xia & He Publishing Inc. Apr 18 2025 Background and aims Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms. However, research on COX-2 regulation of ferroptosis in chronic liver injury remains limited. This study aimed to investigate whether and how COX-2 regulates ferroptosis in chronic liver injury. Methods In vivo , a thioacetamide (TAA)-induced chronic liver injury model, characterized by