Getty San Francisco 49ers GM John Lynch and RB Christian McCaffrey The San Francisco 49ers have been one of the more snake-bitten teams in the NFL over the last few seasons when it comes to injuries. The team had 15 players end their season either on injured reserve or the reserve/non-football injury list in 2025, which hampered San Francisco’s run in the postseason. The offense was ravaged with quarterback Kurtis Rourke , running back Patrick Taylor Jr., wide receivers Brandon Aiyuk , Trent