By Vijay Kumar Malesu Reviewed by Susha Cheriyedath, M.Sc. Mar 30 2025 A new study reveals how sucralose may backfire by boosting hunger-related brain activity—especially in women and those with obesity—challenging its role in weight management strategies. Study: Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weight s. Image Credit: SabOlga / Shutterstock In a recent study published in the journal Nature Metabolism , researchers investigated how