Most weight lost on GLP-1 drugs returns within a year after stopping
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By Dr. Liji Thomas, MD Reviewed by Lauren Hardaker Mar 9 2026 Stopping popular GLP-1 weight-loss drugs may reverse much of their benefit within a year, according to a large modeling analysis, raising questions about how long patients may need to stay on treatment to sustain meaningful weight loss. Study: Trajectory of weight regain after cessation of GLP-1 receptor agonists: a systematic review and nonlinear meta-regression. Image credit: Matt Fowler KC/Shutterstock.com Glucagon -like peptide-
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