Metformin targets the gut instead of the liver to lower glucose

Mihaela Măncilă

Northwestern University May 8 2026 For decades, physicians and scientists thought metformin, the leading Type 2 diabetes medication taken by millions worldwide, mainly targets the liver to suppress glucose production. But a new Northwestern University study in mice has found this "wonder drug" instead focuses primarily on the gut, acting to prevent glucose levels rising in the blood by driving glucose utilization inside cells lining the intestine.  The body relies on glucose as a fast and

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