Popular drugs for diabetes and weight loss, like Ozempic, Wegovy, and Mounjaro, can have profound impacts on the body, but what about the brain ? These medicines are thought to broadly suppress appetite and enhance feelings of fullness, but the actual way they achieve that in the human brain is poorly understood. The first in-human investigation of its kind has found that tirzepatide (brand name: Mounjaro) may modulate a specific brain signal, possibly involved in dysregulated eating. The study