New insights into pathogenic T cells offer hope for Crohn's disease treatment
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The University of Osaka Sep 4 2025 The research group led by Drs. Mitsuru Arase, Mari Murakami, and Prof. Kiyoshi Takeda (Graduate School of Medicine/ Immunology Frontier Research Center at The University of Osaka) revealed that transcription factors RUNX2 and BHLHE40 play crucial roles in inducing T cells involved in Crohn's disease. Crohn's disease is an intractable disorder characterized by chronic inflammation in the digestive tract. Tissue-resident memory T cells (T RM ), which persist in
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